sartorius single use stirred cell culture liter scale publication stedim bioreactors str source

Single-use Stirred Tank Bioreactors - Pall Corporation

Single-use Stirred Tank Bioreactors - Pall Corporation

As more and more single-use bioreactors and bags are used in late-phase and commercial production, especially with the availability of 2000-L single-use stirred tank bioreactors, the need for consistent bag quality, robustness, improved assurance of supply, change management, and business continuity planning become crucial. The BIOSTAT® A is available with single-wall glass vessels in a choice of working volumes of 1, 2 or 5 liters maximum. Whether you select our reusable UniVessel® Glass version or our disposable UniVessel® SU unit with a maximum 2-liter working volume, you can use the same system controller.

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Single-use disposable technologies for biopharmaceutical ...

Single-use disposable technologies for biopharmaceutical ...

with Allegro™ Single-Use Stirred Tank Bioreactors A unique square design provides significant benefits over traditional cylindrical cell culture bioreactors. Download our poster to learn how this novel single-use technology can help you achieve successful cell culture scale-up from the benchtop to cGMP manufacturing. To date, however, only a five-fold volume expansion is achievable in a single-use stirred tank bioreactor, which in turn, necessitates intermediate equipment to scale up the culture to production ...

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(PDF) Dynamic Single-Use Bioreactors Used in Modern Liter ...

(PDF) Dynamic Single-Use Bioreactors Used in Modern Liter ...

Today Sartorius offers a wide variety of single-use bioreactors which are ideal for mammalian cell culture, very demanding high cell-density or microcarrier-based processes. Our single-use bioreactors from 15 mL working volume with Ambr® 15 to Biostat® STR 2,000 L have been developed to ensure easy and straightforward scale-up and scale-down. High throughput automated fermentation systems have become a useful tool in early bioprocess development. In this study, we investigated a 24 x 15 mL single use microbioreactor system, ambr 15f, designed for microbial culture.

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Verification of New Flexsafe STR Single-Use Bioreactor ...

Verification of New Flexsafe STR Single-Use Bioreactor ...

Figure 2 compares cell growth and viability data of the high–cell-density fed-batch run at 1,000-L scale with data from 50-L scale using the single-use BIOSTAT STR bioreactor set-up. Our large-scale, single-use, bag-based bioreactors achieved excellent comparability in both runs. Relevance to Single-Use Bioreactors: Determining k L a can be especially useful when companies make decisions about the role of single-use bioreactors in their overall manufacturing strategy. For those considering adopting single-use bioreactor technology and thinking about where and how to do so, k L a measurements can provide meaningful support for big investment decisions.

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Single‐Use Stirred Tank Reactor BIOSTAT CultiBag STR ...

Single‐Use Stirred Tank Reactor BIOSTAT CultiBag STR ...

Classic stirred-tank design ensures seamless scale conversion to the Biostat® STR single-use bioreactor and also to stainless steel equipment for large-scale manufacturing. Advanced analytical capabilities including online glucose and lactate measurement, off-gas measurement and viable biomass/ cell density measurement allow predictive process modelling and control. Sartorius offers classic stirred-tank design in single-use bioreactors, from Ambr® 250 to Biostat® STR 2000. Watch this video to learn more about successful single-use processing. Interview with Gerben Zijlstra on New Tools for Intensified Bioprocessing, ESACT 2019

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Single-Use Bioreactors-An Overview | Request PDF

Single-Use Bioreactors-An Overview | Request PDF

Sartorius Stedim Biotech offers classic stirred-tank design in single-use bioreactors, from ambr ® 250 to BIOSTAT STR 2000. – Geometrical similarity of vessel design – Consistent mixing and gassing strategies – Reliable single-use sensor platform Simplify your scale-up and scale-down studies The largest main culture bioreactors (1000–2000 L) were inoculated with a pre-culture in a stirred-tank bioreactor (BIOSTAT ® STR 200/500, Sartorius Stedim Biotech). The temperature set point was chosen at 36.8 °C and the pH was controlled at 7.1 (for Process A) and 7.15 (for Process B) …

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Single-Use Bioprocessing | Thermo Fisher Scientific - US

Single-Use Bioprocessing | Thermo Fisher Scientific - US

Sartorius Stedim Biotech (SSB) today introduced the ambr® 250 modular, an innovative benchtop mini bioreactor system for parallel fermentation or cell culture. This system combines a unique single-use bioreactor vessel and expandable system design to offer bioprocess scientists access to advanced benchtop bioreactor technology for process development. The stirred single-use cell culture bioreactors from Sartorius Stedim with the UniVessel SU (a) and the BIOSTAT CultiBag STR with a working volume of 50 L (b) +6 Evaluation of the BIOSTAT CultiBag ...

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Sartorius Stedim Biotech Introduces Mini Microcarrier ...

Sartorius Stedim Biotech Introduces Mini Microcarrier ...

Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, announced the launch of its next generation BIOSTAT STR®, a fully scalable, single-use bioreactor family based on a conventional stirred-tank design. Sartorius Stedim Biotech, , August-Spindler-Str.11, 37079 Goettingen, Germany UniVessel® SU Design The UniVessel SU is a single-use bioreactor that meets the design criteria of conven-tional glass, stainless steel and state-of-the-art larger scale single-use stirred tank bioreactors. The culture …

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Sartorius Stedim Biotech Launches Innovative ambr 250 ...

Sartorius Stedim Biotech Launches Innovative ambr 250 ...

The BIOSTAT STR family is a range of completely single-use bioreactors with a conventional stirred-tank design that is ideal for high-density cell culture applications. The range has true scalability from process development through pilot to production scales, minimizing both the effort associated with scaling up cell culture processes and the risk of process transfer even to larger-scale ... EquipNet is the world’s leading provider of used bioreactors and various other preowned equipment. Our exclusive contracts with our clients yield a wide range of used bioreactors from a number of respected OEMs, including Wave Biotech, Thermo Scientific, B. Braun Biotech, New Brunswick Scientific, Precision Stainless, Xcellerex, Lee Industries, and many more.

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Measuring kLa for Better Bioreactor Performance ...

Measuring kLa for Better Bioreactor Performance ...

New vessel for ambr® 250 ht system will enable cost-effective, scalable process development of vaccines in cell culture. Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry announce the launch of a new mini bioreactor vessel for its ambr® 250 high throughput (ht) system. This new vessel, which is designed for optimal growth of adherent cells on ...  · Single-use, stirred bioreactors with rigid vessels, such as the BioBLU single-use vessels from Eppendorf , , , the Ambr 250 , , the UniVessel SU from Sartorius Stedim Biotech , , the Mobius CellReady 3 L bioreactor from Merck Millipore , , and the SmartVessel single-use bioreactor from Finesse Solutions, Inc., are close to the classic design of reusable, stirred-tank bioreactors.

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Sartorius Stedim Biotech introduces new BIOSTAT STR ...

Sartorius Stedim Biotech introduces new BIOSTAT STR ...

 · Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, announced the launch of its next generation BIOSTAT STR ®, a fully scalable, single-use bioreactor family based on a conventional stirred-tank design.. This new bioreactor range featuring upgraded hardware and software, as well as a fully integrated, new design of Flexsafe STR ® single-use ... Biostat STR® is engineered for highly efficient mixing and high oxygen transfer. In addition to the standard features, you can incorporate advanced options such as an integrated spectroscopy port, Repligen’s XCell™ ATF cell retention device, BioPAT® process control tools and software, and sophisticated analytics.

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High throughput automated microbial bioreactor system …

High throughput automated microbial bioreactor system …

However, a direct comparison of the influence of single-use wave-mixed and single-use stirred bioreactors on cell growth and protein expression in Sf-9/BEVS-based production processes was still ... Single-use technology at bioreactors. Single-use bioreactors are widely used in the field of mammalian cell culture and are now rapidly replacing conventional bioreactors.. Instead of a culture vessel made from stainless steel or glass, a single-use bioreactor is equipped with a disposable bag.

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Stainless Steel Bioreactors & Fermenters | Sartorius

Stainless Steel Bioreactors & Fermenters | Sartorius

New generation of bioreactors combined with new Flexsafe STR® bags offer a fully scalable, single-use system. Systems enable significant reduction of bioprocess development timelines and costs. Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, announced the launch of its next generation BIOSTAT STR®, a fully scalable, single-use bioreactor ... stirred cell culture bioreactors ... (Sartorius Stedim ... there remains a requirement for rapid bioprocess development and scale up. Here, single use bioreactors are of interest due to the ...

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